신정욱 교수님

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신정욱 교수님

신정욱 교수님

신정욱 교수님

[ 세 포 및 생 체 역 학 연 구 실 ]

 

신정욱 교수님

학력 및 전공

- 연구실 : 하연관(A) 309  

- 전화 :(교내) 3317  

- 이메일 :(sjw@bse.inje.ac.kr )

-홈페이지 : http://cellmech.inje.ac.kr

-서울대학교 공과대학기계공학과(공학사) 

-미국 Georgia Institute of Technology    

기계과(공학석사) 

-미국 Georgia Institute of Technology    

기계과(공학박사)

 

세포생체역학(Cell Biomechanics)

생체역학(Biomechanics) 인체내의 혈관, 근육등의 Soft tissue 역학적 거동에 대한 연구는 병의 진단과치료, 나아가서는 대체장기의 개발에 필수 불가결한 분야이다. 이를 위하여는 정상및 비정상상태 장기의 거동과 역학적 물성치연구와 모델링이 필요하다. 예로, 각막의 물성치에 대한 연구는 근시및 난시 교정수술에 결정적인 자료를 제공한다.

2000년부터는 조직공학이나 성체줄기세포의 생체유사환경조절과 같은 세포와 관련된 분야의 연구를 수행해 왔다. 이러한 세포 공학적 접근에 기초하여 세포를 인체 내에서 경험하는 것과 같은 환경에서 배양 분석하였다. 2008년에 임상의와 생물학자, Bio-MEMS (biological microelectromechanical system) MRS (magnetic resonance spectroscopy) 전문가들이 모여 광범위한 연구와 관련된 방법론들을 위한 국가 지정 연구실로 지정되었다.

 

경 력

2006.03~현재

인제대학교 의용공학과

교수

 

2000.03~2006.02

인제대학교 의용공학과

부교수

 

1999.03~2000.02

미국 Duke 대학교

방문교수

정형외과연구실

1995.03~1999.02

인제대학교 의용공학과

조교수

 

1993.03~1995.02

인제대학교 의용공학과

전임강사

 

 

국내 외 학()회 활동

연도(부터-까지)

()회명

직책

2009 - 현재

Journal of Clinical Rehabilitative Tissue Engineering

International Editor Board

 

2008 - 현재

대한기계학회 (바이오공학부문)

부회장

 

2007 - 현재

대한생체역학회

학술이사

 

2006 - 현재

생체재료학회

평의원

 

2006 - 현재

SPRBM (Society of Physical Regulation in Biology and Medicine)

회원

 

2004 - 현재

한국 조직공학 재생의학회

편집위원

 

2000 - 현재

대한정형외과연구학회

평의원

 

1997 - 현재

대한의용생체공학회

학술이사

 

1999 - 2001

ORS (Orthopaedic Research Society)

회원

 

 

수상경력

2009

8 부산과학기술상

국내공훈상

2009

인제대학교 학술상

(Indistinguished scholarship award)

대학학술상

2007

보건산업기술대상전 우수연구자상

(보건복지부 장관상)

본시멘트 개발연구

2006

보건산업기술대상전 우수상

(보건산업지흥원장상)

국내최초 골수복제 완성, 출시 인정

 

연구논문 발표 실적 등

 

() 국외 전문 학술지 (2006 이후)

1. Jie Wei, Junfeng Jia, FanWu, Shicheng Wei, Huanjun Zhou, Hongbo Zhang, Jung-Woog Shin, Changsheng Liu

"Hierarchically microporous/macroporous scaffold of magnesium-calcium phosphate for bone tissue regeneration" Biomaterials; 2010; 31(6);1260-1269.

2. Dong Hwa Kim, Su-Jin Heo, Jung-Woog Shin, Chi Woong Mun, Kyung Min Park, Ki Dong Park, Kyoung Soo Jee "Preparation of Thermosensitive Gelatin-Pluronic® Copolymer for Cartilage Tissue Engineering" Macromolecular Research, 2010;18(4)

3. Jie Wei, S. J. Heo, Changsheng Liu, D. H. Kim, S. E. Kim, Y. T. Hyun, Ji-Wang Shin, Jung-Woog Shin "Preparation and characterization of bioactive calcium silicate and poly(-caprolactone) nanocomposite for bone tissue regeneration" Journal of Biomedical Materials Research Part A; 2009;90(3);702-712

4. Jie Wei, S. J. Heo, Changsheng Liu, D. H. Kim, S. E. Kim, Y. T. Hyun, Ji-Wang Shin, Jung-Woog Shin "Preparation and characterization of bioactive calcium silicate and poly(-caprolactone) nanocomposite for bone tissue regeneration Journal of Biomedical Materials Research Part A;2009;

5. Jie Wei, Xiaohui Wu, Changsheng Liu, Junfeng Jia, Su-jin Heo, Seung-eon Kim, Yong-taek Hyun, Jung-Woog Shin "Fabrication of Bioactive Scaffold of Poly(e-Caprolactone) and Nanofiber Wollastonite Composite Journal of the American Ceramic Society;2009;92(5);1017-1023.

6. Su-Jin Heo, Seung-Eon Kim, Jie Wei, Dong Hwa Kim, Young-Taek Hyun, Hui-Suk Yun, Hyung Keun Kim, Taek Rim Yoon, Su-Hyang Kim, Su-A Park, Ji Won Shin, Jung-Woog Shin "In Vitro and Animal Study of Novel Nano - Hydroxyapatite / Poly (varepsilon-Caprolactone) Composite Scaffolds Fabricated by Layer Manufacturing ProcessTissue Engineering: Part A;2009;15(5);977-989.

7. Ji Won Shin, Yong Jae Lee, Su Jin Heo, Su A Park, Su-Hyang Kim, Young Jick Kim, Dong-Hwa Kim and Jung-Woog Shin Manufacturing of multi-layered nanofibrous structures composed of polyurethane and poly(ethylene oxide) as potential blood vessel scaffolds Journal of Biomaterial Science; Polymer Edition; 2009; 20; 757-771.

8. Su-Jin Heo, Seung-Eon Kim, Jie Wei, Yong-Taek Hyun, Hui-Suk Yun, Dong-Hwa Kim, Ji Won Shin, Jung-Woog Shin Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process Journal of Biomedical Materials Research Part A;2009;89(1);108-116.

9. Jie Wei, Fangping Chen, Jung-Woog Shin, Hua Hong, Chenglong Dai, Jiancan Su,Changsheng Liu "Preparation and characterization of bioactive mesoporous wollastonite - Polycaprolactone composite scaffold Biomaterials; 2009; 30; 1080 - 1088.

10. Dong Hwa Kim, Su-Hyang Kim, Su-Jin Heo, Ji Won Shin, Shi Woo Lee, Su-A Park, Jung-Woog Shin "Enhanced differentiation of mesenchymal stem cells into NP-like cells via 3D co-culturing with mechanical stimulation" Journal of Bioscience and Bioengineering;2009;108(1);63-67.

11. Jie Wei, Fangping Chen, Jung-Woog Shin, Hua Hong, Chenglong Dai, Jiancan Su,Changsheng Liu "Preparation and characterization of bioactive mesoporous wollastonite - Polycaprolactone composite scaffold" Biomaterials;2009;30;1080-1088.

12. Hui-suk Yun, Seung-eon Kim, Yong-taek Hyun, Su-jin Heo, Jung-woog Shin "Hierarchically mesoporous-macroporous bioactive glasses scaffolds for bone tissue regeneration" Journal of Biomedical Materials Research Part B: Applied Biomaterials";2008;87B;374-380.

13. Ji Won Shin, Yong Jae Lee, Su Jin Heo, Su A Park, Su-Hyang Kim, Young Jick Kim, Dong-Hwa Kim and Jung-Woog Shin "Manufacturing of multi-layered nanofibrous structures composed of polyurethane and poly(ethylene oxide) as potential blood vessel scaffolds" Journal of Biomaterial Science; Polymer Edition;2008;

14. Seung Hwan Han, Yun Hee Kim, Min Sung Park, In Ae Kim, Jung -Woog Shin, Woo Ick Yang, Kyoung Soo Jee, Ki Dong Park, Gyu Ha Ryu, Jin Woo Lee "Histological and biomechanical properties of regenerated articular cartilage using chondrogenic bone marrow stromal cells with a PLGA scaffold in vivo" Journal of Biomedical Materials Research Part A;2008;87(4);850-861.

15. 1. Su-Jin Heo, Seung-Eon Kim, Jie Wei, Dong Hwa Kim, Young-Taek Hyun, Hui-Suk Yun, Hyung Keun Kim, Taek Rim Yoon, Su-Hyang Kim, Su-A Park, Ji Won Shin, Jung-Woog Shin "In Vitro and Animal Study of Novel Nano-HA/PCL Composite Scaffolds Fabricated by Layer Manufacturing Process" Tissue Engineering: Part A;2008;14

16. Su-Jin Heo, Seung-Eon Kim, Jie Wei, Yong-Taek Hyun, Hui-Suk Yun, Dong-Hwa Kim, Ji Won Shin, Jung-Woog Shin "Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process" Journal of Biomedical Materials Research Part A;2008

17. Jong Young Kim, Eui Kyun Park, Shin-Yoon Kim, Jung-Woog Shin, Dong-Woo Cho "Fabrication of SFF based Three-dimensional Scaffold using precise deposition system in tissue engineering" Journal of Micromechanics and Microengineering;2008;18(5);1-7.

18. Kim Young Jick, Park Su A, Lee Yong Jae, Shin Ji Won, Kim Dong Hwa, Heo Su Jin, Park Ki Dong, Shin Jung Woog "Effects of intermittent hydrostatic pressure on cell adhesive forces and other related parameters under various resting periods" Journal of Biomedical Materials Research Part B;2008;85B(2);353-360.

19. Park Kyung Min, Bae Jin Woo, Joung Yoon Ki, Shin Jung Woog, Park Ki Dong. " Nanoaggregate of thermosensitive chitosan-Pluronic for sustained release of hydrophobic drug." Colloids and Surfaces B Biointerfaces;2008;63;1-6.

20. Yun Hui-suk, Kim Seung-eon, Hyun Yong-Taek, Heo Su-jin, Shin Jung-woog "Three-Dimensional Mesoporous-Ginatporous Inorganic/Organic Composite scaffolds for Tissue Engineering." Chemistry of Materials;2007;19(26);6363-6366.

21. Wei jie, Heo SJ, Kim DH, Kim SE, Hyun YT, Shin JW "Comparison of physical, chemical and cellualr responses to nano- and micro-sized calcium silicate/poly(ε-caprolactone) bioactive composites.". Journal of the royal society interface;2007;1-14.

22. Kim Hyo Joo, Bae Jin woo, Kim chun ho, Lee jin woo, Shin Jung-woog, Park ki dong. "Acellular matrix of bovine pericardium bound with L-arginine" Biomedical Materials;2007;2;S111-S116.

23. Sang Gil Lee, Eun young An, Jung Bok Lee, Jong Chul Park, Jung-Woog Shin and Jeong Koo Kim "Enhanced cell affinity of poly (D,L-lactic-co-glycolic acid) (50/50) by plasma treatment with β-(13)(16)-glucan" Surface & Coatings Technology;2007;201:5128-5131.

24. Y.J.Lee, I.A.Kim, S.A.Park, W.J.Shin, C.W.Kim, J.W.Bae, K.D. Park, and J.W.Shin "A Tissue Engineering Based Approach to Regeneration of Intervertebral Disc." Key engineering and materials;2007;397-400.

25. Heo SJ, Park SA, Shin HJ, Lee YJ, Yoon TR, Seo HY, Ahn KC, Kim SE, Shin JW. "Evaluation of Bonding Stress for the Newly Suggested Bone Cement: Comparision with Currently Used PMMA through Animal Studies." Key engineering and materials;2007;373-376.

26. Heo SJ, Kim SE, Hyun YT, Kim DH, Lee HM, Hwang YM, Park SA, Shin JW. "In Vitro Evaluation of Poly(ε-caprolactone)/Hydroxyapatite Composites as Scaffolds for Bone Tissue Engineering with Human Bone Marrow Stromal Cells." Key engineering and materials;2007;369-372.

27. Hyun YT, Kim SE, Heo SJ, Shin JW "Characterization of PCL/HA composite scaffolds bone tissue engineering." Key engineering and materials;2007:109-112.

28. Kim SE, Hyun YT, Chung DJ, Heo SJ, Shin JW, Lee JH. "Biodegradable porous PCL/HA scaffolds for bone tissue engineering." Key engineering and materials 2007:77-80.

29. Shin JW, Kim YJ, Kim JH, Lee YJ, Heo SJ, Hwang YM, Kim DH, Shin JW "The effects of cyclic strains on the hybrid aligned nanofibrous scaffold seeded with smooth muscle cells." Molecular & Cellular Biomechanics;2006;3(4):223-224.

30. Heo SJ, Kim SE, Hyun YT, Kim DH, Kim JH, Lee YJ, Kim YJ, Shin JW, Hwang YM, Shin JW "Fabrication of Porous Scaffolds for Bone Tissue Engineering Using a 3-D Robotic System : Comparison with Conventional Scaffolds Fabricated by Particulate Leaching." Molecular & Cellular Biomechanics;2006;3(4):179-180.

31. Kim SH, Choi YR, Park MS, Shin JW, Park KD, Kim SJ, Lee JW. "ERK 1/2 activation in enhanced osteogenesis of human mesenchymal stem cells in poly(lactic-glycolic acid) by cyclic hydrostatic pressure." Journal of biomedical materials research. Part A;2006;80(4);826-836.

32. Su A Park, In Ae Kim, Yong Jae Lee, Ji Won Shin, Chong-Rak Kim, Jeong Koo Kim, Young-Ii Yang, and Jung-Woog Shin "Biological responses of ligament fibroblasts and gene expression profiling on micropatterened silicone substrates subjected to mechanical stimuli." Journal of Bioscience and Bioengineering; 2006; 102(5) : 402-412.

33. Kim IA, Park SA, Kim YJ, Kim SH, Shin HJ, Lee YJ, Kang SG, Shin JW "Effects of Mechanical Stimuli and Microfiber-based Substrate on Neurite Outgrowth and Guidance." Journal of Bioscience and Bioengineering;2006;101(2):120-126.

34. Park HD, Bae JW, Park KD, Ooya T, Yui N, Jang JH, Han DK, Shin JW "Surface Modification of Polyurethane Using Sulfonated PEG Grafted Polyrotaxane for Improved Biocompatibility." Macromolecular Research;2006;14(1):73-80.

35. Shin HJ, Lee CH, Cho IH, Kim YJ, Lee YJ, Kim IA, Park KD, Yui N, Shin JW "Electrospun PLGA nanofiber scaffolds for articular cartilage : mechanical stability, degradation and cellular responses undermechanical stimulation in vitro." Journal of Biomaterial Sciences Polymer Edition;2006;17(1-2):103-119.

 

() 국내 전문 학술지 (2006 이후)

1. Su-Hyang Kim, So Hee Park, Jae Woo Jun, Dong Hwa Kim, Ji Won Shin, Jeong Yoon Han, Yun Gyeong Kang, and Jung-Woog Shin "Hydrostatic Pressure can Control Osteogenesis and Osteoclastogenesis when Stromal Cells and Osteoclast Precursor Cells are Cocultured" Tissue Engineering and Regenerative Medicine; 2010;7(4); 388-394

2. 정재영, 김동화, 박소희, 신지원, 한정윤, 강윤경, 신정욱 "PDMS 표면형상과 간헐적 정수압이 중간엽 줄기세포의 분화 증식에 미치는 영향" Tissue Engineering and Regenerative Medicine; 2010;7(3);283-290

3. 이시우, 장지연, 박소희, 김동화, 신지원, 김수향, 신정욱 "혈관 미세 유체환경에서 혈관 내피 세포와 공배양된 중간엽 줄기세포의 특성 관찰" Tissue Engineering and Regenerative Medicine; 2010;7(2);255-261

4. 이시우, 허수진, 장지연, 정재영, 김수향, 박수아, 전은수, 신정욱형상이 제어된 조직 재생용 3차원 지지체를 적용한 새로운 형태의 Perfusion Culture Tissue Engineering and Regenerative Medicine;2010;7(1);9-15

5. 엄태관, 서승우, 전계록, 신정욱, 정창모 "임플란트 지대주나사의 조임회전력이 연결부 안정성에 미치는 영향에 관한 3차원 유한요소해석 연구대한치과보철학회지;47(2);125-135.

6. 김동화, 허수진, 신지원, 박소희, 신정욱 "기계적 자극이 3차원 공배양을 통한 중간엽 줄기세포의 chondrogenesis 미치는 영향" Tissue engineering and regenerative medicine;2009;6(4-11); 739-745.

7. 안기찬, 최장석, 김태형, 이용재, 윤택림, 신정욱, 정훈재, 김상우 " 고온 열처리한 돼지해면골의 생체적합성에 대한 평가 -동물 실험 임상 실험 보고" 대한정형외과연구학회지;2009;12(1); 33-44.

8. 하상훈, 김동화, 신정욱, 곽희철, 최장석 "추간판 수핵 대체를 위한 생체 재료와 기계적 자극의 영향" 대한정형외과연구학회지;2009;12(2); 45-52

9. Kim DH, Kim SH, Heo SJ, Shin JW, Kim YJ, Park SH, Jun JW , Shin JW "The Differentiation of bone marrow stromal cells into NP-like Cells through 3-Dimensional co-culture system" Journal of Biomedical Engineering Research;2008;29(2);159-163

10. Park KM, Kim DH, Bae JW, Jeong Yk, Shin JW, Park KD "Injectable chioan-pluronic yrogel releasiing osteogenic protein-1 for the regeneration of intervetebral disc" Biomaterials Research; 2008;12(1);24-27

11. Shin JW, Kim DH, Heo SJ, Kim SH, Kim YJ, Shin JW "Effects of the Mechanical Stretch on Aligned Multi-Layered Nanofibrous Scaffolds Seeded with Smooth Muscle Cells" Journal of Biomedical Engineering Research;2008;29(1);52-58

12. Kim MD, Shin JW, Kim IA, Park SA, Eom TG, Shin JW "Study of Titanium Surface Characteristics Treated with Alkali after Anodic Oxidation" Biomaterial Research;2007;11(4);170-175

13. Lee YJ, Shin JW, Shin HJ, Kim CH, Park KD, Bae JW, Seo HY, Kim YJ, Shin JW "Investigation of nanofiber and thermosensitive scaffold for intervertebral disc through organ culture." Korean society of medical & biological engineering;2007;28(4);512-519

14. Heo SJ, Kim SE, Wei Jie, Heon YT, Kim DH, Youn HS, Shin JW, Hwang YM, Shin JW "Effects of HA paticle sizes on proliferation of osteoblasts in novel 3-dimensional HA/PCL scaffolds" Biomaterials Research 2007;11(2):70-74.

15. Eom SH, Jeon GR, Kim HI, Kim YJ, Kim MD, Shin JW "The effects of IHP on MG-63 cells seeded on anodic oxidized titanium" Biomaterials Research 2007;11(1):30-35.

16. Shin JW, Shin HJ, Heo SJ, Kim JH, Hwang YM, Kim DH, Shin JW "Dual Electrospinning to Manufacture Hybrid Nanofibrous Scaffold using Polyurethane and Poly(Ethylene Oxide)" J. Biomed. Eng. Res. 2006:27(5); 224-228.

17. Park SA, Kim IA, Kim CR, Shin JW, Heo SJ, Hwang YM, Kim DH, Shin JW "Effects of mechanical stimuli on the cell proliferation and collagen production on the micropatterened substrate." J. Exp. Biomed. Sci. 2006;12:119-125.

18. Park SA, Kim IA, Lee YJ, Hwang YM, Kim DH, Seo SS, Shin JW "Cell arrangement on micropatterned substrate in response to mechanical stretching" Biomaterials Research 2006;10(2):48-54.

19. Heon YT, Kim SE, Heo SJ, Shin JW, Lee HM, Moon SY. "Fabrication and Assessment of Hydroxyapatite/poly-ε-caprolactone Composite Scaffolds" 대한금속 재료학회지 2006;44(6):381-385.

 

특허/프로그램 출원등록실적

1. 조직 재생용 칩의 제조방법 (출원, 대한민국, 2009.11.03.)

2. 나노크기의 생체 재료와 생분해성 고분자와의 복합체 제조방법 (출원, 대한민국, 2008.03.31)

3. 나노크기의 칼슘 실리케이트계 생체재료 입자의 제조방법 (출원, 대한민국, 2008.03.31)

4. 나노크기의 인산칼슘계 생체재료 입자의 제조방법 나노크기의 인산칼슘계 생체재료 입자 (출원, 대한민국, 2008.02.28)

5. 돼지의 해면골을 취하여 무기물화함으로써 골이식용 해면골의 기초 본블록을 제조하는 방법 (등록, 대한민국, 2007.02.01)

 

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